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Despite the promising preclinical data, the efficacy of cannabinoids modulating IBS-associated abdominal pain has been difficult to prove in a clinical context, at least as it relates to the use of tetrahydrocannabinols [THC and dronabinol] [133,143]

"Hepatocyte-specificGclcdeletion leads to rapid onset of steatosis with mitochondrial injury and liver failure"

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