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(2022 )Astrocytic Nrf2 expression protects spinal cord from oxidative stress following spinal cord injury in a male mouse model. Journal of neuroinflammation , doi: Wang H et al (2022) Melatonin Attenuates Spinal Cord Injury in Mice by Activating the Nrf2/ARE Signaling Pathway to Inhibit the NLRP3 Inflammasome

Amyloid aggregates may then induce further microglial dysfunction exacerbating a vicious cycle of neuro-inflammation and progression of disease

Multiple observational studies have found that individuals with low B12 are significantly more likely to report depressive symptoms, and intervention studies show that correcting the deficiency improves mood outcomes sometimes substantially