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The ratio [GSH]/[GSSG] is thought to be around 100 for cells that are not under oxidative stress [41], and [GSH]/[GSSG] = 107.5 in our model cell

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29 Similar to cisplatin, TMZ also targets DNA, producing several types of base lesions through methylation, and the alkylated product O 6 -methylguanine (O 6 MeG) is particularly harmful to the cells