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nucleatum increases proliferation of colorectal cancer cells and tumor development in mice by activating toll-like receptor 4 signaling (TLR4) to nuclear factor -B (NF-B), and up-regulating expression of microRNA-21 (Yang et al., 2017)

It is important to note that the neurogenesis hypothesis of depression is somewhat controversial because depression-like symptoms can occur even when cell proliferation is not decreased and the behavioral actions of antidepressants do not always coincide with increases in the number of hippocampal neurons (Surget et al., 2008

These often-overlooked members are now recognized as integral to intestinal ecology, able to reshape microbial balance and modulate host immunity through distinct metabolic and immunological pathways 2,6