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References Heffernan M, Summers RJ, Thorburn A, Ogru E, Gianello R, Jiang WJ, et al

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Preclinical studies found that treating neuronal, nematode, or rodent AD models with NR resulted in induction of a mitochondrial stress response, including UPR mt and mitophagy, reduced proteotoxic stress, and decreased A accumulation 243

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