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The VB2 metabolism gene signature consists of seven genes ( SLC52A1, SLC52A2, SLC52A3, RFK, FLAD1, ACP5 , and ENPP1 ) based on the Reactome pathway database ( The CD8T signature included twelve genes ( CD3D, CD3E, CD3G, CD8A, CD8B, GZMB, GZMA, NKG7, GZMK, PRF1, CD44 , and CD69 ) as previously described 41

After myocardial infarction, macrophages and other inflammatory cells infiltrate the infarct area, leading to the production of pro-inflammatory cytokines, exacerbating inflammation, and clearing necrotic tissue (180)