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While the primate studies found no evidence of ectopic fat accumulation in the liver or arterial walls, the concern remains valid for larger-scale or longer-duration use

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Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumor growth in vivo

Furthermore, two-year EDSS change and PIRA were associated to higher global MFIS and BDI-II scores suggesting a potential usefulness of baseline PRO measures to detect patients at risk of progression