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This Notch intracellular domain then translocates to the nucleus, where it forms a complex with CSL and Mastermind-like, regulating target gene expression and influencing critical cellular processes such as inflammation, apoptosis, and proliferation, which are crucial to the pathogenesis of PH as demonstrated by several clinical and preclinical studies (Fig

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On days 4 and 8, NRF2-deficient mice displayed more severe lesions that did not show significant improvement following SFN treatment (Fig