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Vaginal delivery has emerged as another promising method while transdermal systems such as nanoethosomes provide the benefit of avoiding hepatic metabolism and improving patient compliance through non-invasive application [217]

In another glutamatergic-targeted study, NitroSynapsin administration in Mef2c +/ mice increased the number of NeuN-positive cells and the levels of VGAT and parvalbumin-positive synapses, without altering the number of parvalbumin-positive neurons within the hippocampus