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Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)/SIRT1 reduction

This makes it easier to maintain a calorie deficit without constantly battling cravings

Given that age influences, but does not fully determine, prevalent AHM use, sub-analysing them separately ensured that the effects of each factor were appropriately examined without conflating their impacts

Bradshaw RT, Dziedzic J, Skylaris CK, Essex JW (2020) The role of electrostatics in enzymes: do biomolecular force fields reflect protein electric fields