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Observational and experimental studies, which have thus far been more focused on other gastrointestinal diseases like IBD, are required to further assess these markers in relation to prediction of CRC development risk and progression, and to further define the mechanisms of carcinogenesis in interaction with lifestyle and microbiome factors

Regular monitoring and follow-up visits are an integral part of our patient-centered approach to ensure proper dosage, assess therapeutic effectiveness, and proactively manage potential complications associated with long-term vitamin B12 deficiency

There is some human data in obesity trials