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This could also be the case for some mitochondrial proteins like Complex I and Odh which seem to be quite sensitive to S-glutathionylation (Beer et al., Enzymatically driven protein S-glutathionylation reactions It has long been known that cytosolic thiol oxidoreductase glutaredoxin-1 (Grx1) catalyzes the deglutathionylation of cytosolic proteins (Mannervik and Axelsson, 1980)

Although we did not find any significant difference between soluble Flt-1, also known as vascular endothelial growth factor receptor 1, levels in the plasma of R and LC patients, LC group exhibits a significant plasma elevation compared to the HC cohort ( Figure 6I )

Copley and Jasvinder K

28 Approach to management The management of migraine can be broken into three pillars: lifestyle management, acute treatment and preventive treatment