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Cumulative scores are calculated using, for nucleotide sequences, the parameters M (reward score for a pair of matching residues

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Intriguingly, CBS and CSE are also secreted by microvascular endothelial cells and hepatocytes into the bloodstream, supporting the presence of an extracellular transsulfuration system that produces H 2 S starting from Hcy and protects the endothelium from Hcy-induced oxidative stress from the outside [63]