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Challenges and Future Directions of Nasal-Brain Delivery Despite the significant promise of nasal nano-delivery systems for CNS disease treatment, their clinical translation remains constrained by a series of complex and challenges, including concerns over long-term biological safety, difficulties in scalable and reproducible manufacturing, and the absence of clear regulatory frameworks for approval

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The ways in which astrocytes regulate the metabolism of glucose, amino acids, and lipids have all been implicated in neurological diseases