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UV can only indirectly affect the internal organs, because for the most part, it does not penetrate the body any deeper than the skin

A lack of glutathione in the antigen presenting cell (APC) will result in an inhibition of the THl cytokine production in favor of a TH2 response (Peterson)

A significant association between gasdermin E (GSDME) and cfDNA has been observed in RA patients, further experiments have demonstrated that NETs triggered NF-B/Caspase 3/GSDME-mediated pyroptosis in fibroblast-like synoviocytes (FLSs), indicating that pyroptosis is a source of cfDNA (46)

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