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Under physiological conditions, ferritin-bound or excess Fe 2+ is delivered to lysosomes via NCOA4-mediated ferritinophagy or through direct uptake by transporters such as ZIP8, ZIP14, and DMT1

The age-standardized prevalence, incidence, and years lived with disability have increased by 8% to 10% since 1990

Hepatic knockdown of GADD45 enhances hepatic lipogenenic gene expression in MCD diet-fed mice To investigate how GADD45 knockdown aggravates hepatic steatosis, we compared the expression of lipogenesis-related genes in the livers of GADD45-knockdown and control mice fed an MCD diet

In terms of mechanism, DNA damage repair is the most critical reason for the radiotherapy resistance of GH and IGF1 in cancer cells and damage repair effect on adjacent tissues