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Then, cancer cell invasion into LVs is facilitated by the high interstitial fluid pressure inside the tumor (138) ( Figure 4A )

One exceptional example is that the application of pharmacological intervention with the SLC1A5 inhibitor V9302 demonstrated remarkable selectivity in blocking glutamine uptake specifically in TNBC cells, while leaving CD8 + T cells unaffected [134]

This is particularly powerful because it can reveal mechanisms of action that weren't previously suspected

In addition, transcription factorsincluding Fos , Junb and Egr1 were also upregulated, which is consistent with our transcriptomic analysis of Caco-2 cells treated with clofazimine (Extended Data Fig