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Discussion Leveraging a genome-wide CRISPR screening strategy, we identified pathways that enhance cell fitness in response to dysfunctional mitochondrial protein synthesis

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In IBD, chronic inflammation disrupts this stabilitypathogenic bacteria (e.g., Ruminococcus gnavus ) proliferate rapidly, while beneficial taxa (e.g., Faecalibacterium prausnitzii ) decline, leading to chaotic microbial fluctuations and reduced diversity ( Lactobacillus rhamnosus GG (LGG, 10 9 CFU/day) markedly improved microbiota diversity, reversing dysbiosis by enriching beneficial taxa such as Bifidobacterium, Olsenella, Paenibacillus , and butyrate-producing bacteria ( Zhiphyllobacterium, Osteobacillus , and Desulphurobacteria , thereby alleviating colonic inflammation in UC mouse models ( Under physiological conditions, the mucus layer segregates luminal bacteria from intestinal epithelial cells (IECs), and the immune system maintains tolerance toward luminal antigens ( Metabolic studies further link microbial composition to functional pathways

Distinct brain networks underlie cognitive dysfunction in Parkinson and Alzheimer diseases