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In experiments, rats were equipped with optical devices that provided blue light and was converted into near-infrared light by upconversion microcapsules, which enabled the secretion of intestinal endocrine hormones under external control for therapeutic purposes (81)

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Moreover, it has been shown that receptor-interacting serinethreonine-protein kinase 3 a key mediator of necroptosis is much more highly expressed in cholangiocytes than in hepatocytes, which is associated with a switch from sublethal necrosome activation in hepatocytes to lethal necroptosis in cholangiocytes 175

However, these drugs can lead to adverse effects, including systemic exposure through nasal absorption and localized irritation [84, 85]