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This method can identify the alterations of proteins carried by LDL-Ps, even modifications of these proteins, in combination with MALDI mass spectrometry, thereby providing another way for examination of changes associated with ASCVD ( Nuclear magnetic resonance In the 1 H-NMR spectrum, the terminal methyl protons of lipids under different chemical environments may exhibit distinct chemical shifts, which can be used to determine the LDL subclasses by comparation with the data documented in the libraries ( 1 H-NMR data, the concentration of the LDL subclasses can be calculated as well as their size and lipid mass ( Fast protein liquid chromatography Fast protein liquid chromatography (FPLC) method for detection of lipoprotein subclasses including LDL subclasses have been reviewed by Okazaki and Yamashita (Okazaki and Yamashita, 2016) and Kanonidou (Okazaki and Yamashita, 2016)

[DOI] [PMC free article] [PubMed] [Google Scholar] 315.Yuki K., Murat D., Kimura I., Ohtake Y., Tsubota K