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Biomedical applications RSSP in RBCs The protocol described in this manuscript for the detection of GSSP in RBCs as biomarkers of oxidative stress was applied in our laboratory to human and rat samples

10.1038/s41401-023-01156-w 103 WangB.YangL.-N.YangL.-T.LiangY.GuoF.FuP.et al (2023b)

Clin Infect Dis (1999) 29:4523

In terms of antioxidant effects, flavonoids activate the Nrf2/antioxidant response element (ARE) pathway, upregulating the expression and activity of antioxidant substances such as heme oxygenase-1 (HO-1), superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH), while reducing the levels of malondialdehyde (MDA), lipid peroxides (LPO), and excess nitric oxide (NO), thereby alleviating intestinal oxidative damage (Lyu et al., 2022