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The pathological basis of diabetic complications, including DPN, often involves oxidative damage from chronic hyperglycemia (103)

Without an adequate supply of these vitamins, the livers ability to produce glutathione is compromised

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They also found that 4-HNE production in OA articular tissues contributed to inflammatory responses by upregulating COX-2 expression and limiting the magnitude of transcriptional expression of iNOS [80]