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Comprehensive transcriptome and proteome analyses have provided global views of mRNA and protein abundance of metabolic enzymes in kidney regions and nephron segments 24,25,26,27 , which are generally consistent with results of previous targeted analyses of enzyme activity, protein abundance, or substrate utilization

Elevated TMAO levels have been associated with increased risks of atherosclerosis, cardiovascular disease, and higher all-cause mortality in multiple epidemiological studies

10.4049/jimmunol.1900039 J

The one clear fact was that patients with duodenal ulcers gave an exaggerated secretory response to histamine, the basis of a diagnostic test' (Black)