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Moreover, rather than damage to the palmar cutaneous branches of the median nerve and local free nerve endings, Vanhees et al proposed a biomechanical origin for pillar pain, citing the division of the flexor retinaculum as the primary cause

Hypoxia-inducible factors (HIFs) play a critical role in the regulating this adaptive process and controlling the expression of genes associated with cancer development and resistance to treatment [4,5]