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The formation of new blood vessels in the ischemized areas represents one of the approaches used in the treatment of brain stroke [46]

Notably, NO is a signaling molecule produced by nitric oxide synthases (NOS), including endothelial (eNOS), neuronal (nNOS), and inducible (iNOS) nitric oxide synthases 76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91