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In db/db mice, previous studies found that AMPK activation could reduce ROS production and increase mitochondrial biogenesis and ETC activity to alleviate kidney damage in diabetic models[150, 151]

Suh JH, Shenvi SV, Dixon BM, Liu H, Jaiswal AK, Liu RM, Hagen TM (2004) Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid

To address this core pain point, two upgraded solutions have emerged: Liposomal-Glutathione (Lipo-GSH) and S-Acetyl-L-Glutathione (SAG)

Vascular SMC culture and calcification induction study A7r5 rat thoracic aortic SMCs were maintained in DMEM supplemented with high glucose (HyClone, USA), 10% FBS, and 100 units/mL penicillin and 100 g/mL streptomycin (HyClone, USA) at 37 C under a humidified atmosphere of 5% CO 2