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with possibly toxic action at the vascular level

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Its protective effect on podocytes is achieved through upregulation of p-AMPK, downregulation of p-mTOR, and upregulation of p-ULK1 (Wang et al., 2018).Cyanidin-3-O-glucoside (C3G), derived from Morus alba L., black rice, and other sources, protects against HG-induced podocyte dysfunction by improving autophagy and reducing cell apoptosis and EMT

All patients showed a tendency of improvement of clinical manifestations by week 54 of combined MT + IF treatment: reduction of joint syndrome intensity, time of morning stiffness, pain and swelling of the affected joints, which was expressed in reduction of patient-defined VAS indices (on average, from 66.7 to 18.4 mm) and DAS28-CRP(4) (on average, from 5.5 to 3.03)