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When administered at therapeutic levels, APAP is primarily metabolized via the glucuronidation pathway, producing non-toxic metabolites that the liver and kidneys can further process (Chiew and Isbister 2023)

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Jean-Philippe R, Mehdi K, Christophe R, Michel D, Graldine B, Yves M (2007) Inactivation of Thioredoxin Reductases reveals a Complex interplay between Thioredoxin and glutathione pathways in Arabidopsis Development, the Plant Cell

5mTHF also fluctuates but in the opposite direction from homocysteine for two reasons