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It belongs to the group of inflammatory bowel diseases (IBD) and manifests as a chronic inflammatory process in the bowel, marked by periods of clinical relapse and remission [5,6,7]

GhoS and GhoT genes form an operon and are expressed together, although studies have introduced one gene or the other into cells [5]

Upstream regulatory pathways and transcription factors p53 pathway p53 is a master stress-responsive transcription factor that governs cell-cycle arrest, senescence and apoptosis, and its functional inactivation represents a central event in tumorigenesis

However, because of the side effects of long term use of hydroquinone, it is not prescribed long term