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Stage 1 Fat begins to accumulate in the liver tissue, but at this stage, there are no symptoms of inflammation or fibrosis

Br J Clin Pharmacol 71:2028 Shayiq RM, Roberts DW, Rothstein K, Snawder JE, Benson W, Ma X, Black M (1999) Repeat exposure to incremental doses of acetaminophen provides protection against acetaminophen-induced lethality in mice: an explanation for high acetaminophen dosage in humans without hepatic injury

This indicates that augmenting the function of missing beneficial microbes can tip the immune balance toward regulation rather than autoimmunity

Oral antibiotics relieve allergic asthma in post-weaning mice via reducing iNKT cells and function of ADRB2