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BBB blood- brain barrier most approaches to delivery have utilized gene therapy methods with the hope that the growth factor will be expressed in the correct location at a high enough concentration and for a long enough period to provide clinical relief

EMBO Molecular Medicine, 15 (11), e18506

The interaction of NQO1 with SIRT1 is markedly increased under mitochondrial inhibition

Here, the sodium salts of, for example, l-hydroxyethane-l,l-diphosphonate, diethy- lenetriamine pentamethylene phosphonate or ethylenediamine tetramethylene phospho- nate are used in amounts of 0.1 to 5 wt