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10.1155/2022/5419874 18 BowenW

The Two Structural Modifications and Their Research Significance Analogues with substitutions, deletions, or insertions at the N-terminal end of native IGF-1 were found to reduce binding to IGFBPs and increase bioavailability to IGF-1R on cells a principle exploited in the design of LR3, where the arginine substitution and N-terminal extension together confer superior IGFBP evasion compared to shorter analogues such as Arg3 IGF-1, Gly3 IGF-1, and Des(1-3) IGF-1

ITCs are the most commonly generated breakdown products and are considered as biologically active phytochemicals in plant-insect and plant-pathogen interactions 4,5

3.4 The development of a diagnostic method Yang et al