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10.3389/fmed.2022.839066 157 ZhangL.LiY.YangX.WeiJ.ZhouS.ZhaoZ.et al (2016)

doi: 10.1007/s00401-016-1648-8 21

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In response to hypoxia, cells undergo significant metabolic reprogramming to prioritize anaerobic processes such as glycolysis, thus making hif-1 -dependent shifts in metabolism a significant aspect of the hypoxia response across cells types 4,34