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Conclusion This study confirmed that the hot-melt extruded pranlukast amorphous solid dispersion effectively enhances bioavailability by increasing the dissolution rate and maintains physical stability through optimization using design of experiments (DOEs)

Benzo[a]pyrene phenols are more potent inducers of CYP1A1, CYP1B1 and COX-2 than benzo[a]pyrene glucuronides in cell lines derived from the human aerodigestive tract

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