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The major clinical symptoms include dementia, apathy, social withdrawal, mood swings, depression, disturbed sleep, and delusions

Pralsetinib Pralsetinib is an oral RET-targeted therapy

As AIF deficiency potently compromises OXPHOS [32, 34], it is reasonable to speculate that AIF might be another target by which HIF downregulates mitochondrial respiration

J Neurochem 78:10731082 Tseng H-C, Wang M-H, Chang K-C, Soung H-S, Fang C-H, Lin Y-W, Li K-Y, Yang C-C, Tsai C-C (2020) Protective effect of () epigallocatechin-3-gallate on rotenone-induced parkinsonism-like symptoms in rats