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While the daily dose was sufficient to maintain serum B12 levels above 156 pmol/l in almost all subjects, the weekly dose was only able to do so in 74% of subjects (Sanz-Cuesta, 2020)

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It is the only known circulating orexigenic hormone and signals both on vagal afferents and in the arcuate nucleus where it powerfully enhances NPY orexigenic signaling (176, 177)