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doi: 10.3389/fncel.2024.1403734 Received 19 March 2024 Accepted 13 May 2024 Published 24 June 2024 Volume 18 - 2024 Edited by Gabriel G

Neuroprotective effects of ethanol extract polyscias guilfoylei (EEPG) against glutamate induced neurotoxicity in HT22 cells

This reciprocal positive feedback loopwhere iron overload induces peroxisomal dysfunction, which in turn augments ROS production, and ultimately amplifies ferroptosissustains activation of the ferroptosis-immune-metabolic axis

Its structure features two key modifications that set it apart: An arginine substitution at the third position A 13-amino acid extension at the N-terminus This unique molecular architecture results in a more stable compound with a molecular weight of approximately 9.1 kDa, specifically designed to optimize its performance within the human body