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The contributions of the NIH authors were made as part of their official duties as NIH federal employees, are in compliance with agency policy requirements, and are considered works of the United States Government

The researchers utilized the Achilles functional index (AFI), myeloperoxidase activity, histological inflammatory cell influx, and vascular index as potential markers

More substantial improvements, if they occur, generally become apparent between months four and six

Senescent cells secrete factors known as the senescence-associated secretory phenotype (SASP), which can contribute to chronic inflammation and create a microenvironment favorable for cancer progression