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The significant correlation between Kla-specific genes and lactate accumulation-related genes (e.g., P300, LDHA) reveals that Kla promotes BC progression and immune escape by affecting NK cell function and multiple signaling pathways (NOTCH, WNT, among others) (117)

Apoptosis related spot like protein knockout (ASC -/- ) and IL-1R1 -/- mice demonstrated reduced lung inflammation and increased survival rates following H7N9 infection