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J Cell Biol 219:e202004062 Ogawa S, Oki S, Suami T (1979) Inositol derivatives

We and others have shown that short-term glucose stimulation, which increases prooxidant status via cytoplasmic NOX4, is necessary for efficient insulin secretion, whereas long-term stimulation, which tends to induce oxidative stress, can lead to the development of T2D ( The most important, but still technically elusive problem in redox signaling is the compartmentalization of redox status