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In the present review, we will focus mainly on the signaling cascade of TLR4 because it is believed to be the main sensor of bacterial LPS (Ignacio et al., 2016)

With regard to the TGF--mediated EMT pathway, several studies have mentioned that the pro-inflammatory cytokines IL-6, IL-17, and IL-22, which share this pathway, are also involved in the fibrotic mechanism of SG (53, 55, 57)