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These cells are susceptible to protein aggregate accumulation, which increases proteotoxicity and genotoxicity that can lead to HCC development

4.2.3 Fenton reaction The Fenton reaction, a redox interaction between iron and hydrogen peroxide, generates hydroxyl radicalshighly reactive and cytotoxic species that drive ferroptosis by abstracting hydrogen atoms from lipids to initiate non-enzymatic lipid peroxidation (Zhu et al., 2022