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Therapy 33 BoscoA.CrishS.SteeleM.RomeroC.InmanD.HornerP.et al (2012)

Less consistent evidence across analyses were found for an association between higher C3 levels and an anhedonic symptom profile previously linked with inflammation and neurobiological reward processes

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Dopamine release is mediated by voltage-gated calcium channels that trigger exocytosis of dopamine-filled vesicles into the synaptic cleft, where dopamine binds to its target receptors