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Originally developed to help treat heroin addiction, lower doses of naltrexone have shown a range of remarkable immunological activities

Silverstein RL, Febbraio M (2009) CD36, a scavenger receptor involved in immunity, metabolism, angiogenesis, and behavior

132 5-AMP activated protein kinase (AMPK) is a key regulator of cellular metabolism and energy balance in many aging-related diseases, such as type 2 diabetes, cancer, hyperlipidemia and OA