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Second, the specific roles of obesity and aging in OA pathogenesis remain incompletely defined and may vary across different populations, contributing to inconsistencies in current findings

also reported that higher-dose anti-angiogenic therapy could activate PI3K signaling in myeloid cells that promotes immune suppression and neovascularization 40

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Also, more detailed data are revealed by studies on the immunology modifications that vaccinations can cause, creating a connecting link to understand the overlapping pathophysiologies