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Proinflammatory stimuli such as LPS, IL-6, and IL-1 (144) increase the expression of HCA2 in macrophages, and colony-stimulating factor 2 (CSF2) augment the level of HCA2 expression in neutrophils (151)

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Rutin has also been shown to help microglia uptake extracellular tau oligomers, thereby directly combating AD (253)