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Metallothioneins, a family of cysteine-rich proteins, also contribute significantly to regulating the availability of metal ions, thereby reducing their participation in oxidative damage and the ferroptosis process in human liver cancer cells (HepG2) [141]

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The residues of the key 6 YGS 8 motif within the GCT fold are located in loop 1, while the unique dimerization loop 2 is flipped away from the enzymes core domain (Nguyen et al., 2020)