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On the other hand, selenium in the appropriate dose range plays a central role in the prevention and modulation of several diseases, including inflammatory bowel disease (IBD), cancer, diabetes, metabolic syndrome, neurodegenerative diseases, cardiovascular diseases, fertility disorders, inflammation, and infections, mainly due to the biological functions of selenoproteins exerted by essential enzymes in vivo 2,11

Damage by iron and hydrogen peroxide in vitro and in vivo

Superoxide dismutase (Cu/Zn-SOD), another copper-dependent enzyme, is the most important antioxidant enzyme in the cytoplasm

Reported tolerability in the available human observational work is high: no consistent pattern of adverse effects has been published, although the absence of placebo-controlled trials means subtle effects cannot be excluded