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Yet, it remains unclear whether ferroptosis serves primarily as a downstream effector, an upstream driver, or part of a self-amplifying feedback loop in disease progression

Methods: This retrospective cohort study included all adult heart transplants performed at our center from January 2018 to September 2022

Alleviating inflammation Oxygen glucose deprivation/reoxygenation (OGD/R) or I/R induced the upregulation of inducible nitric oxide synthase (iNOS), cyclooxygenases 2 (COX2) and the releasing of proinflammatory cytokine interleukin 1 beta (IL-1) and tumor necrosis factor- (TNF-) (Chen et al., 2018)