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The visual inspection of the funnel plot suggested the absence of publication bias and small-study effect regardless of the treatment strategy, as shown in supplemental Figure 1

Clinically, melatonin has been reported to reduce the risk of hemorrhagic transformation after tissue plasminogen activator (t-PA) therapy in ischemic stroke (150, 151), suggesting a potential role in improving thrombolytic safety through modulation of BBB permeability

Mitochondrial mass was not significantly changed following IGF-1 treatment of Th17 cells from either control or IR cKO mice (Fig